TY - JOUR AU - Vladimir Zaichick AU - Sofia Zaichick PY - 2018/03/20 Y2 - 2024/03/19 TI - Effect of age on chemical element contents in female thyroid investigated by some nuclear analytical methods JF - MicroMedicine JA - MMED VL - 6 IS - 1 SE - Research Articles DO - UR - http://www.journals.tmkarpinski.com/index.php/mmed/article/view/33 AB - A prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of chemical element contents in thyroid may play an important role in goitro- and carcinogenesis of gland. The variation with age of the mass fraction of twenty chemical elements (Ag, Br, Ca, Cl, Co, Cr, Cu, Fe, Hg, I, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Sr, and Zn) in intact (normal) thyroid of 33 females (mean age 54.5 years, range 3.5-87) was investigated by energy dispersive X-ray fluorescent analysis and instrumental neutron activation analysis with high resolution spectrometry of short- and long-lived radionuclides. This work revealed that there is an increase in Br, Ca, Co, Fe, Rb, Sb, Se, and Zn mass fraction, as well as a decrease in Cl mass fraction in the normal thyroid of female during a lifespan. Therefore, a goitrogenic and carcinogenic effect of inadequate Br, Ca, Co, Fe, Rb, Sb, Se, and Zn level in the thyroid of old females with increasing age may be assumed. ER -