Effect of age on the Br, Fe, Rb, Sr, and Zn concentrations in human prostatic fluid investigated by energy-dispersive X-ray fluorescent microanalysis
Keywords:
Human prostatic fluid, Trace element variations with age, Energy dispersive X-ray fluorescent analysis
Abstract
The effect of age on Br, Fe, Rb, Sr, and Zn concentrations in human prostatic fluid was investigated by 109Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis. Specimens of expressed prostatic fluid were obtained from 51 men (mean age 51 years, range 18-82 years) with apparently normal prostates using standard rectal massage procedure. Mean values (M ± SΕΜ) for concentration of trace elements (mg·l-1) in human prostate fluid were: Br 3.58±0.59, Fe 9.04±1.21, Rb 1.10±0.08, Sr 1.08±0.17, and Zn 573±35. An age-related increase in Zn content and decrease in Br and Fe concentration was observed.
References
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21. Zaichick S, Zaichick V. The effect of age on Ag, Co, Cr, Fe, Hg, Sb, Sc, Se, and Zn contents in intact human prostate investigated by neutron activation analysis. Appl Radiat Isot. 2011; 69: 827-833.
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28. Zaichick V, Zaichick S. The distribution of 54 trace elements including zinc in pediatric and nonhyperplastic young adult prostate gland tissues. J Clin Lab Invest Updates. 2014; 2(1): 1-15.
29. Zaichick V, Zaichick S. INAA application in the assessment of chemical element mass fractions in adult and geriatric prostate glands. Appl Radiat Isot. 2014; 90: 62-73.
30. Zaichick V, Zaichick S. Determination of trace elements in adults and geriatric prostate combining neutron activation with inductively coupled plasma atomic emission spectrometry. Open J Biochem. 2014; 1(2): 16-33.
31. Zaichick V, Zaichick S. Use of INAA and ICP-MS for the assessment of trace element mass fractions in adult and geriatric prostate. J Radioanal Nucl Chem. 2014; 301: 383-397.
32. Zaichick V. The variation with age of 67 macro- and microelement contents in nonhyperplastic prostate glands of adult and elderly males investigated by nuclear analytical and related methods. Biol Trace Elem Res. 2015; 168: 44-56.
33. ZaichickS, Zaichick V. Relations of morphometric parameters to zinc content in paediatric and nonhyperplastic young adult prostate glands. Andrology. 2013; 1: 139-146.
34. Zaichick V, Zaichick S. Relations of bromine, iron, rubidium, strontium, and zinc content to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands. Biol Trace Elem Res. 2014; 157: 195-204.
35. Zaichick V, Zaichick S. Relations of the neutron activation analysis data to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands. Adv Biomed Sci Engin. 2014; 1: 26-42.
36. Zaichick V, Zaichick S. Relations of the Al, B, Ba, Br, Ca, Cl, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Si, Sr, and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands. BioMetals. 2014; 27: 333-348.
37. Zaichick V, Zaichick S. The distribution of 54 trace elements including zinc in pediatric and nonhyperplastic young adult prostate gland tissues. J Clin Lab Invest Updates. 2014; 2(1): 1-15.
38. Zaichick V, Zaichick S. Age-related histological and zinc content changes in adult nonhyperplastic prostate glands. Age. 2014; 36:167-181.
39. Zaichick V, Zaichick S. Androgen-dependent chemical elements of prostate gland. Androl Gynecol Curr Res. 2014; 2(2): 1-9.
40. Zaichick V, Zaichick S. Age-related changes in concentration and histological distribution of Br, Ca, Cl, K, Mg, Mn, and Na in nonhyperplastic prostate of adults. EJBMSR. 2016; 4(2): 31-48.
41. Zaichick V, Zaichick S. Variations in concentration and histological distribution of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn in nonhyperplastic prostate gland throughout adulthood. Jacobs J Cell Mol Biol. 2016; 2(1): 1-16.
42. Zaichick V, Zaichick S. Age-related changes in concentration and histological distribution of 18 chemical elements in nonhyperplastic prostate of adults. WJPMR. 2016; 2(4): 5-18.
43. Zaichick V, Zaichick S. Age-related changes in concentration and histological distribution of 54 trace elements in nonhyperplastic prostate of adults. Int Arch Urol Complic. 2016; 2(2): 1-13.
44. Zaichick V, Zaichick S. Variations in concentration and distribution of several androgen-dependent and -independent trace elements in nonhyperplastic prostate gland tissue throughout adulthood. J Androl Gynaecol. 2016; 4(1): 1-10.
45. Deering RE, Choongkittaworn M, Bigler SA, Aramburu E, King J, Brawer MK. Morphometric quantitation of stroma in human benign prostatic hyperplasia. Urology. 1994; 44: 64-67.
46. Zaichick V. Applications of synthetic reference materials in the medical Radiological Research Centre. Fresenius J Anal Chem. 1995; 352: 219-223.
47. Zaichick V, Sviridova T, Zaichick S. Zinc concentration in human prostatic fluid: normal, chronic prostatitis, adenoma, and cancer. Int Urol Nephrol. 1996; 28(5): 687-694.
48. Zaichick V, Zaichick S, Davydov G. Method and portable facility for measurement of trace element concentration in prostate fluid samples using radionuclide-induced energy-dispersive X-ray fluorescent analysis. Nucl Sci Techn. 2016; 27(6): 1-8.
49. Zaichick V, Tsyb A, Dunchik VN, Sviridova TV. Method for diagnostics of prostate diseases. Certificate of invention No 997281 (30.03.1981).
50. Burgos MH. Biochemical and functional properties related to sperm metabolism and fertility. In: Brandes D, ed. Male accessory sex organs. New York, Academic Press, 1974: 151-160.
51. Gomes Y, Arocha F, Espinoza F, Fernandez D, Vasquez A, Granadillo V. Zinc levels in prostatic fluid of patients with prostate pathologies. Invest Clin. 2007; 48(3): 287-294.
52. Iyengar GV. Reevaluation of the trace element content in reference men. Radiat Phys Chem. 1998; 51(4-6): 545-560.
53. Mackenzie AR, Hall T, Whitmore WF Jr. Zinc content of expressed human prostate fluid. Nature. 1962; 193(4810): 72-73.
54. Fair WR, Cordonnier JJ. The pH of prostatic fluid: a reappraisal and therapeutic implications. J Urol. 1978; 120(6): 695-698.
55. Kavanagh JP, Darby C, Costello CB. The response of seven prostatic fluid components to prostatic disease. Int J Androl. 1982; 5(5): 487-496.
56. Zaichick V. Medical elementology as a new scientific discipline. J Radioanal Nucl Chem. 2006; 269: 303-309.
57. Zaichick V. Sampling, sample storage and preparation of biomaterials for INAA in clinical medicine, occupational and environmental health. In: Harmonization of health-related environmental measurements using nuclear and isotopic techniques. Vienna, International Atomic Energy Agency, 1007: 123-133.
58. Zaichick V. Losses of chemical elements in biological samples under the dry ashing process. Trace Elem Med. 2004; 5(3): 17-22.
59. Moore RA, Miller ML, Mc Lellan A. The chemical composition of prostatic secretion in relation to benign hypertrophy of the prostate. J Urol. 1941; 46: 132-137.
60. Huggins C, Scott WW, Heinen JH. Chemical composition of human semen and of the secretion of the prostate and seminal vesicles. Am J Physiol. 1942; 136(3): 467-473.
2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, RebeloM, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136: E359-E386.
3. Rebbeck TR. Conquering cancer disparities: new opportunities for cancer epidemiology, biomarker, and prevention research. Cancer Epidemiol Biomarkers Prev. 2006; 15: 1569-1571.
4. Aslam R, Neubauer S. Dairy foods, milk, calcium, and risk of prostate cancer. Oncol Nutr Connect. 2013; 21: 3-10.
5. Aune D, Rosenblatt DAN, Chan DS, Vieira AR, Vieira R, Greenwood DC, et al. Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies. American Journal of Clinical Nutrition, 2015; 101(1):87-117.
6. Gallus S, Foschi R, Negri E, Talamini R, Franceschi S, Montella M, et al. Dietary zinc and prostate cancer risk: a case-control study from Italy. Eur Urol. 2007; 52(4): 1052-1056.
7. Park SY, Wilkens LR, Morris JS, Henderson BE, Kolonel LN. Serum zinc and prostate cancer risk in a nested case-control study: the multiethnic cohort. Prostate. 2013; 73(3): 261-266.
8. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2003. CA: Cancer J Clin. 2003; 53: 5-26.
9. Zaichick V. Medical elementology as a new scientific discipline. J Radioanal Nucl Chem. 2006; 269: 303-309.
10. Ektessabi A, Shikine S, Kitamura N, Rokkum M, Johansson C. Distribution and chemical states of iron and chromium released from orthopedic implants into human tissues. X-Ray Spectrom. 2001; 30: 44-48.
11. Yoshida S, Ektessabi A, Fujisawa S. XAFS spectroscopy of a single neuron from a patient with Parkinson’s disease. J Synchrotron Radiat. 2001; 8: 998-1000.
12. Isaacs JT. Prostatic structure and function in relation to the etiology of prostatic cancer. Prostate. 1983; 4(4): 351-366.
13. Zaichick V, Zaichick S. Role of zinc in prostate cancerogenesis. In: Anke M, et al, eds. Mengen und Spurenelemente. 19. Arbeitstagung. Jena, Friedrich-Schiller-Universitat, 1999: 104-115.
14. Zaichick V. INAA and EDXRF applications in the age dynamics assessment of Zn content and distribution in the normal human prostate. J Radioanal Nucl Chem. 2004; 262: 229-234.
15. Zaichick V, Zaichick S. Age-related histological and zinc content changes in adult nonhyperplastic prostate glands. Age. 2014; 36(1): 167-181.
16. Zaichick V, Zaichick S, Wynchank S. Intracellular zinc excess as one of the main factors in the etiology of prostate cancer. J Anal Oncol. 2016; 5(3): 124-131.
17. Zaichick V, Zaichick S, Rossmann M. Intracellular calcium excess as one of the main factors in the etiology of prostate cancer. AIMS Mol Sci. 2016; 3: 635-647.
18. Zaichick S, Zaichick V. Method and portable facility for energy-dispersive X-ray fluorescent analysis of zinc content in needle-biopsy specimens of prostate. X-Ray Spectrom. 2010; 39: 83-89.
19. Zaichick S, Zaichick V. The Br, Fe, Rb, Sr, and Zn content and interrelation in intact and morphologic normal prostate tissue of adult men investigated by energy dispersive X-ray fluorescent analysis. X-Ray Spectrom. 2011; 40: 464-469.
20. Zaichick S, Zaichick V. INAA application in the age dynamics assessment of Br, Ca, Cl, K, Mg, Mn, and Na content in the normal human prostate. J Radioanal Nucl Chem. 2011; 288: 197-202.
21. Zaichick S, Zaichick V. The effect of age on Ag, Co, Cr, Fe, Hg, Sb, Sc, Se, and Zn contents in intact human prostate investigated by neutron activation analysis. Appl Radiat Isot. 2011; 69: 827-833.
22. Zaichick S, Zaichick V, Nosenko S, Moskvina I. Mass fractions of 52 trace elements and zinc trace element content ratios in intact human prostates investigated by inductively coupled plasma mass spectrometry. Biol Trace Elem Res. 2012; 149: 171-183.
23. Zaichick V, Nosenko S, Moskvina I. The effect of age on 12 chemical element contents in the intact prostate of adult men investigated by inductively coupled plasma atomic emission spectrometry. Biol Trace Elem Res. 2012; 147: 49-58.
24. Zaichick V, Zaichick S. The effect of age on Br, Ca, Cl, K, Mg, Mn, and Na mass fraction in pediatric and young adult prostate glands investigated by neutron activation analysis. Appl Radiat Isot. 2013; 82: 145-151.
25. Zaichick V, Zaichick S. INAA application in the assessment of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn mass fraction in pediatric and young adult prostate glands. J Radioanal Nucl Chem. 2013; 298: 1559-1566.
26. Zaichick V, Zaichick S. NAA-SLR and ICP-AES application in the assessment of mass fraction of 19 chemical elements in pediatric and young adult prostate glands. Biol Trace Elem Res. 2013; 156: 357-366.
27. Zaichick V, Zaichick S. Use of neutron activation analysis and inductively coupled plasma mass spectrometry for the determination of trace elements in pediatric and young adult prostate. AJAC. 2013; 4: 696-706.
28. Zaichick V, Zaichick S. The distribution of 54 trace elements including zinc in pediatric and nonhyperplastic young adult prostate gland tissues. J Clin Lab Invest Updates. 2014; 2(1): 1-15.
29. Zaichick V, Zaichick S. INAA application in the assessment of chemical element mass fractions in adult and geriatric prostate glands. Appl Radiat Isot. 2014; 90: 62-73.
30. Zaichick V, Zaichick S. Determination of trace elements in adults and geriatric prostate combining neutron activation with inductively coupled plasma atomic emission spectrometry. Open J Biochem. 2014; 1(2): 16-33.
31. Zaichick V, Zaichick S. Use of INAA and ICP-MS for the assessment of trace element mass fractions in adult and geriatric prostate. J Radioanal Nucl Chem. 2014; 301: 383-397.
32. Zaichick V. The variation with age of 67 macro- and microelement contents in nonhyperplastic prostate glands of adult and elderly males investigated by nuclear analytical and related methods. Biol Trace Elem Res. 2015; 168: 44-56.
33. ZaichickS, Zaichick V. Relations of morphometric parameters to zinc content in paediatric and nonhyperplastic young adult prostate glands. Andrology. 2013; 1: 139-146.
34. Zaichick V, Zaichick S. Relations of bromine, iron, rubidium, strontium, and zinc content to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands. Biol Trace Elem Res. 2014; 157: 195-204.
35. Zaichick V, Zaichick S. Relations of the neutron activation analysis data to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands. Adv Biomed Sci Engin. 2014; 1: 26-42.
36. Zaichick V, Zaichick S. Relations of the Al, B, Ba, Br, Ca, Cl, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Si, Sr, and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands. BioMetals. 2014; 27: 333-348.
37. Zaichick V, Zaichick S. The distribution of 54 trace elements including zinc in pediatric and nonhyperplastic young adult prostate gland tissues. J Clin Lab Invest Updates. 2014; 2(1): 1-15.
38. Zaichick V, Zaichick S. Age-related histological and zinc content changes in adult nonhyperplastic prostate glands. Age. 2014; 36:167-181.
39. Zaichick V, Zaichick S. Androgen-dependent chemical elements of prostate gland. Androl Gynecol Curr Res. 2014; 2(2): 1-9.
40. Zaichick V, Zaichick S. Age-related changes in concentration and histological distribution of Br, Ca, Cl, K, Mg, Mn, and Na in nonhyperplastic prostate of adults. EJBMSR. 2016; 4(2): 31-48.
41. Zaichick V, Zaichick S. Variations in concentration and histological distribution of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn in nonhyperplastic prostate gland throughout adulthood. Jacobs J Cell Mol Biol. 2016; 2(1): 1-16.
42. Zaichick V, Zaichick S. Age-related changes in concentration and histological distribution of 18 chemical elements in nonhyperplastic prostate of adults. WJPMR. 2016; 2(4): 5-18.
43. Zaichick V, Zaichick S. Age-related changes in concentration and histological distribution of 54 trace elements in nonhyperplastic prostate of adults. Int Arch Urol Complic. 2016; 2(2): 1-13.
44. Zaichick V, Zaichick S. Variations in concentration and distribution of several androgen-dependent and -independent trace elements in nonhyperplastic prostate gland tissue throughout adulthood. J Androl Gynaecol. 2016; 4(1): 1-10.
45. Deering RE, Choongkittaworn M, Bigler SA, Aramburu E, King J, Brawer MK. Morphometric quantitation of stroma in human benign prostatic hyperplasia. Urology. 1994; 44: 64-67.
46. Zaichick V. Applications of synthetic reference materials in the medical Radiological Research Centre. Fresenius J Anal Chem. 1995; 352: 219-223.
47. Zaichick V, Sviridova T, Zaichick S. Zinc concentration in human prostatic fluid: normal, chronic prostatitis, adenoma, and cancer. Int Urol Nephrol. 1996; 28(5): 687-694.
48. Zaichick V, Zaichick S, Davydov G. Method and portable facility for measurement of trace element concentration in prostate fluid samples using radionuclide-induced energy-dispersive X-ray fluorescent analysis. Nucl Sci Techn. 2016; 27(6): 1-8.
49. Zaichick V, Tsyb A, Dunchik VN, Sviridova TV. Method for diagnostics of prostate diseases. Certificate of invention No 997281 (30.03.1981).
50. Burgos MH. Biochemical and functional properties related to sperm metabolism and fertility. In: Brandes D, ed. Male accessory sex organs. New York, Academic Press, 1974: 151-160.
51. Gomes Y, Arocha F, Espinoza F, Fernandez D, Vasquez A, Granadillo V. Zinc levels in prostatic fluid of patients with prostate pathologies. Invest Clin. 2007; 48(3): 287-294.
52. Iyengar GV. Reevaluation of the trace element content in reference men. Radiat Phys Chem. 1998; 51(4-6): 545-560.
53. Mackenzie AR, Hall T, Whitmore WF Jr. Zinc content of expressed human prostate fluid. Nature. 1962; 193(4810): 72-73.
54. Fair WR, Cordonnier JJ. The pH of prostatic fluid: a reappraisal and therapeutic implications. J Urol. 1978; 120(6): 695-698.
55. Kavanagh JP, Darby C, Costello CB. The response of seven prostatic fluid components to prostatic disease. Int J Androl. 1982; 5(5): 487-496.
56. Zaichick V. Medical elementology as a new scientific discipline. J Radioanal Nucl Chem. 2006; 269: 303-309.
57. Zaichick V. Sampling, sample storage and preparation of biomaterials for INAA in clinical medicine, occupational and environmental health. In: Harmonization of health-related environmental measurements using nuclear and isotopic techniques. Vienna, International Atomic Energy Agency, 1007: 123-133.
58. Zaichick V. Losses of chemical elements in biological samples under the dry ashing process. Trace Elem Med. 2004; 5(3): 17-22.
59. Moore RA, Miller ML, Mc Lellan A. The chemical composition of prostatic secretion in relation to benign hypertrophy of the prostate. J Urol. 1941; 46: 132-137.
60. Huggins C, Scott WW, Heinen JH. Chemical composition of human semen and of the secretion of the prostate and seminal vesicles. Am J Physiol. 1942; 136(3): 467-473.
Published
2018-10-05
How to Cite
Zaichick, V., & Zaichick, S. (2018). Effect of age on the Br, Fe, Rb, Sr, and Zn concentrations in human prostatic fluid investigated by energy-dispersive X-ray fluorescent microanalysis. MicroMedicine, 6(2), 94-104. Retrieved from http://www.journals.tmkarpinski.com/index.php/mmed/article/view/80
Section
Research Articles
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