Status of iron during radon-sulfide balneotherapy in osteoarthritis patients

Jadwiga Kuciel-Lewandowska, Sylwia Płaczkowska, Lilla Pawlik-Sobecka, Agnieszka Piwowar

Abstract


Osteoarthritis and other arthropathies are still one of the most debilitating musculoskeletal disorders among the elderly population. Pathogenesis of these diseases is multifactorial and mainly connected with increasing of oxidative stress. Pharmacotherapy, physico- and balneotherapy are the most commonly used methods of treatment. The mechanism of action balneotherapy in arthropathies is not fully understood. Probably it is a combined effect of used forms of biological interactions which influence different metabolic pathways. One of the potential factor connected with decreasing oxidative stress status during balneotherapy can be iron bioavailability and changes its concentration during this therapy. The aim of this study was assessing change of iron blood status during the routine 21 days’ radon-sulfide balneotherapy course in patients with osteoarthritis. The study group consisted of 35 osteoarthritis patients without impediment to comprehensive treatment at spa. The age of patients ranged 32-67 years (average 53.5). The blood samples were collected before the therapy and after 21 days of treatment at a spa. The levels of iron, transferrin, total iron binding capacity and transferrin saturation percent were assessed. Within statistical comparison before and after spa course reveled decreasing trend for all iron status parameters after 21 days’ spa treatment, but the observed changes were significant only for TIBC. In the course of spa therapy Osteoarthritis patients, the level of the systemic iron components is not affected and changes in blood oxidative status during this therapy probably are not influenced by iron status and vice versa.

Keywords


Balneotherapy; Iron; Osteoarthritis; Oxidative stress; Radon-sulfide water

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References


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