European Journal of Biological Research <p><strong>ISSN: 2449-8955</strong><br><strong><a title="MNiSW points: 11" href="" target="_blank" rel="noopener">MNiSW points 2016: 11<br></a></strong><strong><a title="ICV: 100.00" href=",p24783440,3.html" target="_blank" rel="noopener">ICV 2017: 100.00</a></strong><br><strong>Acceptance rate: 2016 - 64%, 2017 - 56%</strong><br><strong>Google-based IF (2017): 0.586&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; h-index: 11</strong></p> en-US (Joanna Bródka) (Joanna Bródka) Tue, 15 Jan 2019 20:58:01 +0100 OJS 60 Therapeutic effect of fractionated by ultrafiltration red beetroot (Beta vulgaris L.) juice in rats with food-induced fatty liver <p>The prevalence of non-alcoholic fatty liver disease (NAFLD), being a component of metabolic syndrome, has increased (15-27%) in the industrialized world. The deep mechanism of this pathology is not clear, but it is multifactorial. There is a huge amount of food supplements and medicines with hepatoprotective effect on the market, but the NAFLD problem is far from being resolved. Hepatoprotective products have to provide wide spectra of biological effects, including antioxidant, hypolipidemic, anti-inflammatory action. It is peculiar to natural compounds, including red beetroot juice, which is well known to most of the population. This is important in view of the high prevalence of NAFLD. The aim of this study is to evaluate the curative effect of fractionated by ultrafiltration red beetroot juice in rats with food-induced liver steatosis.</p> <p><strong>DOI: <a href=""></a></strong></p> Dmitry Babarykin, Galina Smirnova, Jurijs Markovs, Svetlana Vasiljeva, Natalija Basova, Raimonds Simanis, Ludmila Viksna ##submission.copyrightStatement## Tue, 15 Jan 2019 20:57:25 +0100 Phenolics content, antiproliferative and antioxidant activities of Algerian Malva sylvestris <p>Due to its expected low toxicity to human use, more attention is given worldwide to antioxidants of natural sources. Therefore, the extraction of the total phenolic compounds contained in the leaves of<em> Malva sylvestris</em> and the analysis of the polyphenols, flavonoids and tannins contents were carried out. The antioxidant activity of the hydro-methanolic extract of <em>Malva sylvestris </em>was investigated employing various established <em>in vitro</em> systems including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, the reduction of hydrogen peroxide and the ferric reducing power assay. The antiproliferative activity of plant extract was tested against three tumor cell lines: MCF-7, Hep2 and WEHI using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphynyl tetrazolium bromide (MTT) assay. Preliminary screening indicated the presence of substances with large therapeutic values: an important content of polyphenols, flavonoids and tannins was detected in the tested extract. Our data showed that the extract exhibited high antioxidant properties, which were demonstrated by its ability to scavenge 76.11% of DPPH free radicals, and the elimination of 69.97% of hydrogen peroxide at a concentration of 125 µg/ml. In addition, the plant extract showed strong ferric reducing power which was a function of the sample concentration. For the antiproliferative activity, the results demonstrated that the plant extract significantly inhibited tumor cell growth and colony formation in a concentration-dependent manner. The toxicity percentage of extract at 125 µg/ml on MCF-7, Hep2 and WEHI was found in the order of 45.20%, 62.62% and 82.04%, respectively.</p> <p><strong>DOI: <a href=""></a></strong></p> Hanane Messaoud Boutennoun, Lilia Boussoufe, Mohamed Kebieche, Khaled Al-Qaoud, Khodir Madani ##submission.copyrightStatement## Mon, 21 Jan 2019 21:49:17 +0100