European Journal of Biological Research http://www.journals.tmkarpinski.com/index.php/ejbr <p><strong>ISSN: 2449-8955</strong><br><strong><a title="MNiSW points: 11" href="http://www.nauka.gov.pl/g2/oryginal/2016_12/c5c2fcb0c283a9eb3d1081020fd3178c.pdf" target="_blank" rel="noopener">MNiSW points 2016: 11<br></a></strong><strong><a title="ICV: 100.00" href="http://journals.indexcopernicus.com/European+Journal+of,p24783440,3.html" target="_blank" rel="noopener">ICV 2017: 100.00</a></strong><br><strong>Acceptance rate: 2016 - 64%, 2017 - 56%</strong><br><strong>Google-based IF (2017): 0.586&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; h-index: 11</strong></p> JBródka Publisher en-US European Journal of Biological Research 2449-8955 Traditional, nutraceutical and pharmacological approaches of Tamarindus indica (Imli) http://www.journals.tmkarpinski.com/index.php/ejbr/article/view/210 <p>Plants have provided a source of inspiration of novel drug compounds, as plant derived medicines have made large contributions to human health and well-being. An estimate of 75-90% of rural population of the world still relies on herbs for their healthcare. Ayurveda, supposed to be the oldest medical system in the world, provides potential leads to find active and therapeutically useful compounds from plants. Epidemiological studies have consistently demonstrated that consumption of plant- derived foods rich in bioactive phytochemicals have a protective effect against different aliments related to human health.&nbsp; <em>Tamarindus indica</em> is having numerous reported activities like antidiabetic, hypolipidemic, hepatoprotective, anti-ulcer, anti-inflammatory, analgesic, antivenom, antimicrobial, antihelmintic and molluscicidal properties. In spite of these medicinal values this plant is also consumed by rural people as vegetable. It also use as flavoring agent to impart flavor to various dishes and beverage. The present comprehensive review is therefore an effort to give detailed information about botanical description, phytochemical, traditional, nutraceutical and pharmacological approaches of <em>Tamarindus indica</em>.</p> <p><strong>DOI: <a href="http://dx.doi.org/10.5281/zenodo.3344888">http://dx.doi.org/10.5281/zenodo.3344888</a></strong></p> Neelam Soni Vinay Kumar Singh ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 2019-07-18 2019-07-18 9 3 141 154 Lassa fever and the Nigerian experience: a review http://www.journals.tmkarpinski.com/index.php/ejbr/article/view/218 <p>The occurrence, transmission and intervention strategies on the Lassa fever disease in Nigeria are presented. The Lassa virus is an enveloped, single stranded, bi-segmented RNA virus that belong to the Arenaviridae family was first reported in 1969 from Lassa village, Borno State, Nigeria. The primary animal reservoir for the virus is the multi-mammate rat (<em>Mastomys natalensis</em>). It is transmitted to humans through the excreta of infected carrier, often via contaminated food and human-to-human transmission. The most common treatment intervention is ribavirin which carries out its function by inhibiting virus replication. Extensive investigation is being carried out to arrive at an effective vaccine. Keeping rodents out of homes and food supplies, as well as maintaining effective personal hygiene are the most viable preventive measures against the disease.</p> <p><strong>DOI: <a href="http://dx.doi.org/10.5281/zenodo.3382695">http://dx.doi.org/10.5281/zenodo.3382695</a></strong></p> Samuel Ebiojo Amodu Stephen Oyedele Fapohunda ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 2019-07-18 2019-07-18 9 3 155 164 Irisin - evidence for benefits resulting from physical activity http://www.journals.tmkarpinski.com/index.php/ejbr/article/view/194 <p>Irisin is a myokine with wide metabolic action, which makes it very similar to a hormone. Its serum level depends on the expression of the genes FNDC5 and PGC-1α which, in turn, are induced, among others, by physical activity, especially aerobic exercises. According to many studies, aerobic training lasting for 45-60 minutes significantly increased the level of irisin in blood or muscles, and was considerably more effective than endurance training. Irisin shows protective properties against type 2 diabetes by decreasing insulin-resistance and against atherosclerosis by the improvement of lipid profile and anti-inflammatory action. It helps patients with overweight and obesity struggle with an excess of adipose tissue, and induces the conversion of white adipose tissue to brown. It also improves metabolic profile by the acceleration of metabolism and increase in thermogenesis. This myokine reduces the risk of occurrence of metabolic syndrome. Also, the neuroprotective effect of irisin has been confirmed, which would indicate a tremendous role of physical effort in slowing down the course of neurodegenerative diseases in seniors. In addition, irisin acts through many signal pathways exerting an anti-inflammatory, anti-oxidative, anti-apoptotic and anti-cancer effects, which is a potential therapeutic goal. Unfortunately, further studies concerning irisin are still needed before it can be clinically used. However, already now it may be the tool for psychologists working with persons suffering from overweight, obesity, diabetes, atherosclerosis, metabolic syndrome, neurodegenerative diseases, and many other disorders to motivate them for regular physical effort.</p> <p><strong>DOI: <a href="http://dx.doi.org/10.5281/zenodo.3385065">http://dx.doi.org/10.5281/zenodo.3385065</a></strong></p> Arkadiusz Bociek ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 2019-09-03 2019-09-03 9 3 165 172 Efficacy of octenidine against Pseudomonas aeruginosa strains http://www.journals.tmkarpinski.com/index.php/ejbr/article/view/207 <p><em>Pseudomonas aeruginosa</em> is a Gram-negative bacterium causing skin and soft tissue infections, complicated urinary tract infections, blood infections, and nosocomial (hospital-acquired) infections. One of the most often used antiseptics in the skin and soft tissue infections is octenidine dihydrochloride. The aim of this study was an evaluation of octenidine activity against strains of <em>P. aeruginosa.</em> Additionally, were compared two staining methods (TTC and MTT) for confirmation of bacterial growth. The study involved eight strains of <em>P. aeruginosa</em>. In order to determine the minimum inhibitory concentration (MIC) of octenidine, the microdilution method was used. For bacterial growth detection was used staining method with 2,3,5-triphenyl-tetrazolium chloride (TTC) and with 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT). In the study has been demonstrated the excellent activity of octenidine against all strains of <em>Pseudomonas aeruginosa</em>. For all tested strains, MICs of octenidine were 0.00039% or 0.00078%, what is equivalent to 3.9 µg/ml and 7.8 µg/ml, respectively. In the study, test with MTT for three strains was more sensitive than a test with TTC. Concluding, octenidine is an antiseptic with high efficacy against <em>Pseudomonas aeruginosa </em>strains. Simultaneously, it was stated that a test with MTT is more sensitive than study with TTC.</p> <p><strong>DOI: <a href="http://dx.doi.org/10.5281/zenodo.3339499">http://dx.doi.org/10.5281/zenodo.3339499</a></strong></p> Tomasz M. Karpiński ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 2019-06-18 2019-06-18 9 3 135 140