TY - JOUR AU - Pallab Chakraborty AU - Kaustav Chakraborty PY - 2022/01/01 Y2 - 2024/03/29 TI - Anti-fibrotic agents could be the game-changer for post-COVID-19 pulmonary fibrosis treatment JF - European Journal of Biological Research JA - EJBR VL - 12 IS - 1 SE - Review Articles DO - UR - http://www.journals.tmkarpinski.com/index.php/ejbr/article/view/519 AB - More than 220 countries and territories are globally affected by the recent pandemic COVID-19 which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is possibility of third wave of this pandemic as per epidemiological and public health experts. Besides that post-COVID-19 complications are alarming matter to look upon. Post-COVID-19 complications include several symptoms like as persistent fever; cough; fatigue; headache; attention disorder; dyspnea; anosmia; ageusia; chest pain discomfort; various respiratory illness; acute respiratory distress syndrome (ARDS) etc., and here the things to worry about is the development of pulmonary fibrosis after COVID-19. In some COVID-19 patients, hyper-inflammation in the form of ‘cytokine storm’ along with dysregulated immune response, alveolar epithelial tissue injury and wound repair collectively cause this secondary pulmonary fibrosis. Therefore, using anti-fibrotic agents e.g. pirfenidone, nintedanib and other natural compounds could be meaningful in these circumstances although their efficacy in treating COVID-19 is subject to more detailed laboratory research works. In this review article, we have discussed the progression of pulmonary fibrosis development which is triggered by COVID-19; probable solutions with anti-fibrotic agents including anti-fibrotic drugs, some well-known natural compounds, combined anti-fibrotic therapies; and the current challenges of this field.DOI: http://dx.doi.org/10.5281/zenodo.5813126 ER -