Antifungal and antioxidant activities of Artemisia herba-alba Asso
Keywords:
Artemisia herba-alba Asso, Essential oils, Extracts, Antioxidant activity, Antifungal activity, Toxicity
Abstract
Artemisia herba-alba Asso was used since ancient times as a painkiller of gynecological diseases and in the Moroccan folk medicine to treat chronic disease like diabetes, arterial hypertension. The genus of Artemisia was marked as a member of the family of Asteraceae. White wormwood was mentioned also on the list of the flora of Tell Atlas (Oran) subsector as an abundance species with 93 specimens. Chemical analysis of essential oils obtained from this plant by hydrodistillation, revealed the presence of different chemical species, contains santonin, lactones of sesquiterpenic acids. Flavonoids, coumarins, and tannins were found in extracts. In the most cases, there was no toxic effect observed on animals after receiving repeated or single doses of A. herba-alba Asso either in the form of extracts or essential oils. Essential oils, organic and aqueous extracts of the same plant have shown antioxidant properties against free radicals measured by DPPH, β-carotene-bleaching and metal chelating power tests. There is a great potency of this plant by interacting of its compounds with constituents of fungal cells; chitin, wall of cell, membrane ergosterol and eukaryotic nucleus, and by way of consequence disrupting their synthesis. It is well-known, that the hyphal growth of fungal pathogens was inhibited by sesquiterpenes lactones. This plant seemed potent in term of biological activities and can be used as potential alternative remedies for the treatment of many infectious and oxidative diseases.
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References
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28. Saei-Dehkordi SS, Tajik H, Moradi M, Khalighi-Sigaroodi F. Chemical composition of essential oils in Zataria multiflora Boiss. from different parts of Iran and their radical scavenging and antimicrobial activity. Food Chem Toxicol. 2010; 48: 1562-1567.
29. Cavar S, Maksimovic M, Solic ME, Jerkovic-Mujkic A, Besta R. Chemical composition and antioxidant and antimicrobial activity of two Satureja essential oils. Food Chem. 2008; 111: 648-653.
30. Ricci D, Fraternale D, Giamperi L, Bucchini A, Epifano F, Burini G, Curini M. Chemical composition, antimicrobial and antioxidant activity of the essential oil of Teucrium marum (Lamiaceae). J Ethnopharmacol. 2005; 98: 195-200.
31. Yeddes N, Chérif J, Guyot S, Sotin H, Ayadi M. Comparative Study of Antioxidant Power, Polyphenols, Flavonoids and Betacyanins of the Peel and Pulp of Three Tunisian Opuntia Forms. Antioxidants. 2013; 2: 37-51.
32. Prasad R, Kapoor K. Multidrug Resistance in Yeast Candida. Int Rev Cet. 2005; 242: 215-248.
33. Saleh MA, Belal MH, EL-Baroty G. Fungicidal Activity of Artemisia herba alba Asso (Asteraceae). J Environ Sci Heal B. 2006; 41: 237-244.
34. Marei GIK, Abdel Rasoul MA, Abdelgaleil SAM. Comparative antifungal activities and biochemical effects of monoterpenes on plant pathogenic fungi. Pestic Biochem Phys. 2012; 103: 56-61.
35. Zahraoui M, Ababou B, El Yousfi B, Boukachabine K. Chemical Composition And Antifungal Activity Of Four Essential Oils Against Phytopathogens Responsible For Root Rot Of Wheat In Morocco. J Agric. 2017; 2: 127-138.
36. Cox S, Mann C. Determining the Antimicrobial Actions of Tea Tree Oil. Molecules. 2001; 6: 87-91.
37. Hsu CC, Lai WL, Chuang KC, Lee MH, Tsai YC. The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans. Med Mycol. 2013; 51: 473-482.
38. Picman AK, Schneider EF. Inhibition of fungal growth by selected sesquiterpene lactones. Biochem System Ecol. 1993; 21: 307-314.
39. Marrif HI, Ali BH, Hassan KMJ. Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice. J Ethnopharmacol. 1995; 49: 51-55.
40. Salhi N, Mohammed Saghir SA, Terzi V, Brahmi I, Ghedairi N, Bissati S. Antifungal Activity of Aqueous Extracts of Some Dominant Algerian Medicinal Plants. Biomed Res Int. 2017: 1-6.
41. Morrissey JP, ed. Biological activity of defence-related plant secondary metabolites. In: Osbourn AE, Lanzotti V. Plant derived from natural product synthesis, function, and application. London, Springer, 2009.
42. Morales M, Barcelo A, Ros PMA. Plant stilbenes: recent advances in their chemistry and biology. Adv Plant Physiol. 2000; 3: 39-70.
43. Ya C, Gaffney SH, Lilley TH, Haslam E, eds. Carbohydrate polyphenol complexation. In: Hemingway RW, Karchesy JJ. Chemistry and significance of condensed tannins. New York, Plenum Press, 1988.
44. Soine TO. Naturally occurring coumarins and related physiological activities. J Pharm Sci. 1964; 53: 231-264.
45. Thornes RD, ed. Coumarins: biology, applications and mode of action. New York, John Wiley & Sons, 1997.
46. Zheng J, Ramirez VD. Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br J Pharmacol. 2000; 130: 1115-1123.
47. Hu Y, Zhang J, Kong W, Zhao G, Yang M. Mechanisms of antifungal and antiaflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus. Food Chem. 2017; 220: 1-8.
48. Orhan I, Özçelik B, Karaoğlu T, Şener B. Antiviral and Antimicrobial Profiles of Selected Isoquinoline Alkaloids from Fumaria and Corydalis Species. Zeitschrift Naturforsch C. 2007; 62: 19-26.
49. Goudjil MB, Ladjel S, Bencheikh SE, Hammoya F, Bachagha Bensaci M, Zighmi S, Mehani M. Bioactivity of Artemisia Herba alba essential oil against plant pathogenic fungi. Pharma Chemica. 2016; 8: 46-52.
50. Abu-Darwish MS, Cabral C, Gonçalves MJ, Cavaleiro C, Cruz MT, Efferth T, Salgueiro L. Artemisia herba-alba essential oil from Buseirah (south Jordan): Chemical characterization and assessment of safe antifungal and anti-inflammatory doses. J Ethnopharmacol. 2015; 174: 153-160.
51. Adrian M, Daire X, Jeandet P, Breuil AC, Weston LA, Bessis R, Boudon E. Comparisons of stilbene synthase activity (resveratrol amounts and stilbenes synthase mRNAs levels) in grapevines treated with biotic and abiotic phytoalexin inducers. Am J Enol Viticult. 1997; 48: 394-395.
52. Schulze K, Schreiber L, Szankowski I. Inhibition effects of resveratrol and its glucoside piceid against Venturia inaequalis, the causal agent of apple scab. J Agric Food Chem. 2005; 53: 356-362.
53. Dababneh BF. Antimicrobial activity of selected Jordanian medicinal plant extracts against pathogenic microorganisms. J Food Agric Environ. 2008; 6: 134-139.
2. Ramawat KG, Mérillon JM, eds. Bioactive Molecules and Medicinal Plants. Verlag Springer Science & Business Media, 2008.
3. Aouadj SA, Nasrallah Y, Hasnaoui O. Regional phytogeographic analysis of the flora of the Mounts of Saida (western Algeria): evaluation-restoration report. Biodivers J. 2020; 11: 25-34.
4. Wright CW, eds. Artemisia. London, CRC Press, 2001.
5. Mohamed AH, El-Sayed MA, Hegazy ME, Helaly SE, Esmail AM, Mohamed NS. Chemical Constituents and Biological Activities of Artemisia herba-alba. Rec Nat Prod. 2010; 4: 1-25.
6. IUCN. A guide to medicinal plants in North Africa. Malaga, IUCN Centre for Mediterranean Cooperation, 2005.
7. Boukhennoufa A, Tir Touil Meddah A, Meddah B, Gabaldó JA, Sonnet, P. Comparative Study Of Artemisia Herba Alba Asso And Citrus Aurantium Essential Oils. Microbiol Biotech Food Sci. 2019; 9: 622-627.
8. Mighri H, Hajlaoui H, Akrout A, Najjaa H, Neffati M. Antimicrobial and antioxidant activities of Artemisia herba-alba essential oil cultivated in Tunisian arid zone. C R Chimie. 2010; 13: 380-386.
9. Al-Khazraji SM, Al-Shamaony AL, Twaij HAA. Hypoglycaemic effect of Artemisia herba alba. I. Effect of different parts and influence of the solvent on hypoglycaemic activity. J Ethnopharmacol. 1993; 40: 163-166.
10. Bakkali F, Averbeck S, Averbeck D, Zhiri A, Idaomar M. Cytotoxicity and gene induction by some essential oils in the yeast Saccharomyces cerevisiae. Mutat Res. 2005; 585: 1-13.
11. Iriadam M, Musa D, Gümüflhan H, Baba F. Effects of two Turkish medicinal plants Artemisia herba-alba and Teucrium polium on blood glucose levels and other biochemical parameters in rabbits. J Mol Cell Biol. 2006; 5: 19-24.
12. Moufid A, Eddouks M. Artemisia herba alba: A popular with potential medicinal properties. Pak J Biol Sci. 2012; 15: 1152-1159.
13. Bertella A, Benlahcena K, Abouamamaa S, Pintob Diana CGA, Maamara K, Kihala M, Silvab Artur MS. Artemisia herba-alba Asso essential oil antibacterial activity and acute toxicity. Ind Crop Prod. 2018; 116: 137-143.
14. Lahna A, Benjelloun N, Seddik N, Farida M, Naya A, Oudghiri M. Toxicological Study of the Effect in vivo and in vitro of Artemisia herba-alba Aqueous Extract in Rats. Pharmacogn Res. 2020; 12: 207-211.
15. Abderrahman SM, Shbailat SJ. Genotoxic and cytotoxic effects of Artemisia herba-alba on mammalian cells. Caryologia. 2014; 67: 265-272.
16. Rani V, Yadav UCS, eds. Free Radicals in Human Health and Disease. India, Springer, 2014.
17. Pincemail J, Bonjean K, Cayeux K, Defraigne JO. Mécanismes physiologiques de la défense antioxydante Physiological action of antioxidant defenses. Nutr Clin Metab. 2002; 16: 233-239.
18. Akrout A, El Jani H, Amouri S, Neffati M. Screening of antiradical and antibacterial activities of essential oils of Artemisia campestris l., Artemisia herba alba asso, & Thymus capitatus hoff et link growing wild in the southern of Tunisia. Res Sci Technol. 2010; 2: 29-39.
19. Zouari S, Zouari N, Fakhfakh N , Bougatef A, Ayadi MA, Neffati M. Chemical composition and biological activities of a new essential oil chemotype of Tunisian Artemisia herba alba Asso. J Med Plants Res. 2010; 4: 871-880.
20. Kadri A, Ben Chobba I, Zarai Z, Békir A, Gharsallah N, Damak M, Gdoura R. Chemical constituents and antioxidant activity of the essential oil from aerial parts of Artemisia herba-alba grown in Tunisian semi-arid region. Afr J Biotechnol. 2011; 10: 2923-2929.
21. Bourgou S, Tammar S, Salem N, Mkadmini K, Msaada K. Phenolic Composition, Essential Oil, and Antioxidant Activity in the Aerial Part of Artemisia Herba-Alba from Several Provenances: A Comparative Study. Int J Food Prop. 2015; 19: 549-563.
22. Sbayou H, Boumaza A, Hilali A, Amghar S. Antioxidant properties of Artemisia herba-alba Asso., Mentha pulegium L. and Origanum compactum Benth. essential oils. J Mater Environ Sci. 2016; 8: 2908-2912.
23. Rafiq R, Hayek S, Anyanwu U, Hardy B, Giddings V, Ibrahim S, Kang H. Antibacterial and Antioxidant Activities of Essential Oils from Artemisia herba-alba Asso., Pelargonium capitatum × radens and Laurus nobilis L. Foods. 2016; 5: 1-12.
24. Khennouf S, Iratni N, Baghiani A, Harzallah D, Arrar L. Antioxidant and antibacterial activities of extracts from Artemisia herba alba Asso. leaves and some phenolic compounds. J Med Plant Res. 2010; 13: 1273-280.
25. Khlifi D, Sghaier R M, Amouri S, Laouini D, Hamdi M, Bouajila J. Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. Food Chem Toxicol. 2013; 55: 202-208.
26. Younsi F, Trimech R, Boulila A, Ezzine O, Dhahri S, Boussaid M, Messaoud C. Essential Oil and Phenolic Compounds of Artemisia herba-alba (Asso.): Composition, Antioxidant, Antiacetylcholinesterase, and Antibacterial Activities. Int J Food Prop. 2015; 19: 1425-1438.
27. Boukhennoufa A, Benmaghnia S, Meddah B, Tir Touil Meddah A. Antioxidant activity of extracts formulated from Citrus aurantium and Artemisia herba alba. Eur J Biol Res. 2020; 10: 343-351.
28. Saei-Dehkordi SS, Tajik H, Moradi M, Khalighi-Sigaroodi F. Chemical composition of essential oils in Zataria multiflora Boiss. from different parts of Iran and their radical scavenging and antimicrobial activity. Food Chem Toxicol. 2010; 48: 1562-1567.
29. Cavar S, Maksimovic M, Solic ME, Jerkovic-Mujkic A, Besta R. Chemical composition and antioxidant and antimicrobial activity of two Satureja essential oils. Food Chem. 2008; 111: 648-653.
30. Ricci D, Fraternale D, Giamperi L, Bucchini A, Epifano F, Burini G, Curini M. Chemical composition, antimicrobial and antioxidant activity of the essential oil of Teucrium marum (Lamiaceae). J Ethnopharmacol. 2005; 98: 195-200.
31. Yeddes N, Chérif J, Guyot S, Sotin H, Ayadi M. Comparative Study of Antioxidant Power, Polyphenols, Flavonoids and Betacyanins of the Peel and Pulp of Three Tunisian Opuntia Forms. Antioxidants. 2013; 2: 37-51.
32. Prasad R, Kapoor K. Multidrug Resistance in Yeast Candida. Int Rev Cet. 2005; 242: 215-248.
33. Saleh MA, Belal MH, EL-Baroty G. Fungicidal Activity of Artemisia herba alba Asso (Asteraceae). J Environ Sci Heal B. 2006; 41: 237-244.
34. Marei GIK, Abdel Rasoul MA, Abdelgaleil SAM. Comparative antifungal activities and biochemical effects of monoterpenes on plant pathogenic fungi. Pestic Biochem Phys. 2012; 103: 56-61.
35. Zahraoui M, Ababou B, El Yousfi B, Boukachabine K. Chemical Composition And Antifungal Activity Of Four Essential Oils Against Phytopathogens Responsible For Root Rot Of Wheat In Morocco. J Agric. 2017; 2: 127-138.
36. Cox S, Mann C. Determining the Antimicrobial Actions of Tea Tree Oil. Molecules. 2001; 6: 87-91.
37. Hsu CC, Lai WL, Chuang KC, Lee MH, Tsai YC. The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans. Med Mycol. 2013; 51: 473-482.
38. Picman AK, Schneider EF. Inhibition of fungal growth by selected sesquiterpene lactones. Biochem System Ecol. 1993; 21: 307-314.
39. Marrif HI, Ali BH, Hassan KMJ. Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice. J Ethnopharmacol. 1995; 49: 51-55.
40. Salhi N, Mohammed Saghir SA, Terzi V, Brahmi I, Ghedairi N, Bissati S. Antifungal Activity of Aqueous Extracts of Some Dominant Algerian Medicinal Plants. Biomed Res Int. 2017: 1-6.
41. Morrissey JP, ed. Biological activity of defence-related plant secondary metabolites. In: Osbourn AE, Lanzotti V. Plant derived from natural product synthesis, function, and application. London, Springer, 2009.
42. Morales M, Barcelo A, Ros PMA. Plant stilbenes: recent advances in their chemistry and biology. Adv Plant Physiol. 2000; 3: 39-70.
43. Ya C, Gaffney SH, Lilley TH, Haslam E, eds. Carbohydrate polyphenol complexation. In: Hemingway RW, Karchesy JJ. Chemistry and significance of condensed tannins. New York, Plenum Press, 1988.
44. Soine TO. Naturally occurring coumarins and related physiological activities. J Pharm Sci. 1964; 53: 231-264.
45. Thornes RD, ed. Coumarins: biology, applications and mode of action. New York, John Wiley & Sons, 1997.
46. Zheng J, Ramirez VD. Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br J Pharmacol. 2000; 130: 1115-1123.
47. Hu Y, Zhang J, Kong W, Zhao G, Yang M. Mechanisms of antifungal and antiaflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus. Food Chem. 2017; 220: 1-8.
48. Orhan I, Özçelik B, Karaoğlu T, Şener B. Antiviral and Antimicrobial Profiles of Selected Isoquinoline Alkaloids from Fumaria and Corydalis Species. Zeitschrift Naturforsch C. 2007; 62: 19-26.
49. Goudjil MB, Ladjel S, Bencheikh SE, Hammoya F, Bachagha Bensaci M, Zighmi S, Mehani M. Bioactivity of Artemisia Herba alba essential oil against plant pathogenic fungi. Pharma Chemica. 2016; 8: 46-52.
50. Abu-Darwish MS, Cabral C, Gonçalves MJ, Cavaleiro C, Cruz MT, Efferth T, Salgueiro L. Artemisia herba-alba essential oil from Buseirah (south Jordan): Chemical characterization and assessment of safe antifungal and anti-inflammatory doses. J Ethnopharmacol. 2015; 174: 153-160.
51. Adrian M, Daire X, Jeandet P, Breuil AC, Weston LA, Bessis R, Boudon E. Comparisons of stilbene synthase activity (resveratrol amounts and stilbenes synthase mRNAs levels) in grapevines treated with biotic and abiotic phytoalexin inducers. Am J Enol Viticult. 1997; 48: 394-395.
52. Schulze K, Schreiber L, Szankowski I. Inhibition effects of resveratrol and its glucoside piceid against Venturia inaequalis, the causal agent of apple scab. J Agric Food Chem. 2005; 53: 356-362.
53. Dababneh BF. Antimicrobial activity of selected Jordanian medicinal plant extracts against pathogenic microorganisms. J Food Agric Environ. 2008; 6: 134-139.
Published
2021-10-06
How to Cite
(1)
Boukhennoufa, A.; Benmaghnia, S.; Maizi, Y.; Touil, A.; Meddah, B. Antifungal and Antioxidant Activities of Artemisia Herba-Alba Asso. European Journal of Biological Research 2021, 11, 493-500.
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