Jamun seed and orange peel extracts protects effects of microcystin LR on serum calcium and phosphate of rats

  • Babita Deep Srivastava Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, India
  • Manish Srivastava Department of Chemistry, Digvijai Nath P.G. College, Gorakhpur, India
  • Sunil Kumar Srivastav Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, India
  • Makoto Urata Institute of Noto Satoumi Education Research, Noto‐cho, Ishikawa 927‐0553, Japan; Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto‐cho, Ishikawa 927‐0553, Japan
  • Nobuo Suzuki Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto‐cho, Ishikawa 927‐0553, Japan
  • Ajai Kumar Srivastav Department of Zoology, DDU Gorakhpur University, Gorakhpur 273009, India
Keywords: Cyanobacteria, Microcystin, Serum calcium, Serum phosphate, Jamun seed, Orange peel

Abstract

Wistar rats were treated as Group A: Control; Group B: microcystin LR (MCLR); Group C: microcystin LR and jamun seed extract (MCLR+JSE); Group D: microcystin LR and orange peel extract (MCLR+OPE); Group E: orange peel extract (OPE); Group F: jamun seed extract (JSE). MCLR dose was 10 µg/kg body wt/day whereas OPE and JSE dose was 200 mg/kg body wt/day. Serum calcium and phosphate were analyzed on 15 and 30 day. Serum calcium of rat exposed  for 15 day to MCLR; MCLR+JSE and MCLR+OPE decreased. Although there is little increase in levels of group C and group D  but treatment with OPE and JSE is not able to completely restore decreased calcium levels caused by MCLR. After 30 day calcium decreased after MCLR; MCLR+JSE and MCLR+OPE treatment. Levels in group E and F remain unaltered. Levels in group C and D exhibit elevation as compared to group B which indicates that treatment with OPE and JSE recovered calcium. Serum phosphate decreased after 15 day in MCLR; MCLR+JSE and MCLR+OPE  treated rats. Phosphate levels of group C (compared with group F) and group D (compared with group E) show decrease. After 30 day exposure to MCLR; MCLR+JSE and MCLR+OPE phosphate levels decreased. Levels of group C and D when compared with group B are increased. Phosphate levels of group C (compared with group F) and D (compared with group E) are decreased. This indicates that OPE and JSE treatment provoked some recovery of phosphate levels.

DOI: http://dx.doi.org/10.5281/zenodo.3940650

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Published
2020-07-11
How to Cite
(1)
Srivastava, B.; Srivastava, M.; Srivastav, S.; Urata, M.; Suzuki, N.; Srivastav, A. Jamun Seed and Orange Peel Extracts Protects Effects of Microcystin LR on Serum Calcium and Phosphate of Rats. European Journal of Biological Research 2020, 10, 198-206.
Section
Research Articles