Antifungal activity of Myrtus communis and Zygophyllum album extracts against human pathogenic fungi

  • Asmaa Belmimoun Laboratory of Research, Bioconversion, Engineering Microbiology and Health Safety, University of Mascara, Algeria
  • B. Meddah Laboratory of Research, Bioconversion, Engineering Microbiology and Health Safety, University of Mascara, Algeria
  • A. T. T. Meddah Laboratory of Research, Bioconversion, Engineering Microbiology and Health Safety, University of Mascara, Algeria
  • J. Gabaldon Food Technology Science Department, Católica San Antonio University, Murcia, Spain
  • P. Sonnet Laboratory of Glucides, Team Thera., FRE-CNRS 3517, Faculty of Pharmacy, University of Picardie, Amiens, France
Keywords: Myrtus communis, Zygophyllum album, Essential oils, Phenolic extracts, Antifungal activity


Fungal infections have been increasing in recent years due to a growing number of high-risk patients, particularly immunocompromised hosts. Currently, medicinal plants are known for their properties due to their essential oils and phenolic compounds. They have been empirically used as antimicrobial agents. So the composition of the phenolic extracts and essential oils of Myrtus communis and Zygophyllum album and their antifungal activity on Candida albicansAspergillus fumigatus fungal strains were studied. In this fact, essential oils from the aerial parts of the plant were obtained by hydrodistillation and analyzed by GC and GC-MS, for the phenolic extracts, several extraction methods with a preliminary phytochemical study were applied. The oils showed high contents of α-pinene and cineol for M. communis and verbenone and caryophyllene for the Z. album. The MIC and minimal lethal concentration were used to evaluate the antifungal activity against Candida and Aspergillus strains. Results showed that M. communis and Z. album essential oil and phenolic extracts exhibited a significant activity against clinically relevant fungi, a significant antifungal activity of the two extracts studied (MCA and ZAM) was observed on C. albicans of these, two extracts, MCA was found to be most active with an MFC value of 25 mg/ml versus 100 mg/ml for ZAM. Nevertheless, the essential oils exhibited stronger antifungal activity than the phenolic extracts. The present study indicates that the two medicinal plants have considerable antifungal activity, deserving further investigation for clinical applications.



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How to Cite
Belmimoun, A.; Meddah, B.; Meddah, A.; Gabaldon, J.; Sonnet, P. Antifungal Activity of Myrtus Communis and Zygophyllum Album Extracts Against Human Pathogenic Fungi. European Journal of Biological Research 2020, 10, 45-56.
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